| Pathway Id | ko04120 |
| Class & Sub-Class | Class: Genetic Information Processing Sub-Class: Folding sorting and degradation |
| Description | Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes; named E1 (ubiquitin activating enzyme); E2 (ubiquitin conjugating enzyme); and E3 (ubiquitin ligase). Each E3 has specificity to its substrate; or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type; U-box type; single RING-finger type; and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s; a scaffold-like cullin molecule; adaptor proteins; and a target recognizing subunit that binds substrates. Source: KEGG Database |
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