| Pathway Id | ko02010 |
| Class & Sub-Class | Class: Environmental Information Processing Sub-Class: Membrane transport |
| Description | The ATP-binding cassette (ABC) transporters form one of the largest known protein families; and are widespread in bacteria; archaea; and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions; sugars; lipids; sterols; peptides; proteins; and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments; two peripheral proteins that bind and hydrolyze ATP; and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand; in a typical eukaryotic ABC transporter; the membrane spanning protein and the ATP-binding protein are fused; forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD). Source: KEGG Database |
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